Tafasitamab Antibody

SKU: orb1980313

Description

Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1422527-84-1
MW	147.41 kDa
Purity	99.3% (SEC-HPLC)
Target	Immunology/Inflammation related,Apoptosis

Bioactivity

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In Vivo	In a xenograft tumor model of disseminated BL mice, tafasitamab (2.5 μg/kg, once on day 1) inhibited lymphoma growt.
In Vitro	In an E/T ratio-dependent manner, tafasitamab (XmAb5574) induced cytotoxicity to Mino and Jeko (MCL) cell lines. It also increased antibody-dependent cellular phagocytosis (ADCP) and ant Proliferative activity. Additionally, tafasitamab (XmAb5574) can enhanc the anti Proliferative activity induced by caspase-mediated apoptosi [1. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, CD19, MOR 00208, MOR00208, MOR-00208, Immunology related, Immunologyrelated, Inflammationrelated, Inflammation related, XmAb5574, Tafasitamab, Tafasitamab-cxix

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Gene Symbol

Immunology/Inflammation related,Apoptosis

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