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Tapinarof

SKU: orb1302687

Description

Tapinarof (Benvitimod) is a topical small molecule aryl hydrocarbon receptor (AhR) agonist developed for psoriasis treatment. It modulates immune and keratinocyte pathways, showing efficacy in both in vitro assays and clinical trials for plaque psoriasis.

Research Area

Immunology & Inflammation, Metabolism Research

Images & Validation

Key Properties

CAS Number79338-84-4
MW254.32
Purity100.00%
FormulaC17H18O2
SMILESCC(C)c1c(O)cc(\C=C\c2ccccc2)cc1O
TargetAryl Hydrocarbon Receptor,AhR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.86 mM);DMSO:55 mg/mL (216.26 mM)

Bioactivity

Target IC50
AhR:13 nM(EC50)
In Vivo
Tapinarof mediates its anti-inflammatory effects via the AhR pathway in IMQ-treated mice. In mice expressing AhR on a C57Bl/6 background, both Tapinarof and 6-formylindolo(3,2-b)carbazole (FICZ) significantly lower clinical inflammation scores. Conversely, AhR knockout (KO) mice exhibit no such anti-inflammatory response to Tapinarof. FICZ serves as a benchmark in these experiments, demonstrating comparable reduction in inflammation in wild-type mice, but ineffective in AhR KO mice.
In Vitro
Tapinarof activates the AhR pathway through direct binding, inducing dose-dependent nuclear translocation of AhR in immortalized keratinocytes (HaCaT).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, AhR, Benvitimod, Inhibitor, inhibit, GSK 2894512, GSK2894512, GSK-2894512, WBI 1001, WBI1001, WBI-1001, Tapinarof

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

Tapinarof (orb1302687)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,430.00
25 mg
¥ 2,210.00
50 mg
¥ 2,990.00
100 mg
¥ 4,680.00
200 mg
¥ 7,540.00
DispatchUsually dispatched within 3-5 working days
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