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Tavilermide

SKU: orb1706574

Description

Tavilermide (MIM-D3) is a cyclic peptide and selective Tropomyosin receptor kinase A (TrkA) agonist. It is utilized in research models of dry eye disease, including in vitro assays for neurite outgrowth and in vivo studies for corneal epithelial healing and tear production.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number263251-78-1
MW580.54
Purity98.98%
FormulaC24H32N6O11
SMILESO=C1C=2C(=CC=C(N(=O)=O)C2)OCC[C@@H](C(NCC(O)=O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)N1
TargetTrk receptor
SolubilityNH4OH:30 mg/mL(51.68 mM);H2O:5 mg/mL (8.61 mM)

Bioactivity

In Vitro
Tavilermide, a tyrosine kinase TrkA receptor agonist, is a protease-stabilized cyclic peptide mimetic that has been shown to be a partial TrkA receptor agonist for the treatment of dry eye. Tavilermide exhibits activity similar to that of nerve growth factor (NGF), but does not bind to the p75NTR receptor, and enhances the effects of suboptimal concentrations of effects of NGF.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MIMD3, MIM-D3, Trk receptor, TrkA, Trkreceptor, Tavilermide
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Tavilermide (orb1706574)

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1 mg
¥ 3,120.00
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