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TbPTR1 inhibitor 1

SKU: orb1688127

Description

TbPTR1 inhibitor 1 (compound 5d) is a potent and selective small molecule inhibitor of Trypanosoma brucei pteridine reductase 1 (TbPTR1), exhibiting an IC50 of <0.1 nM against the enzyme and an EC50 of 0.66 µM against the parasite. This compound is a valuable chemical tool for studying folate metabolism in trypanosomes and for anti-trypanosomal drug discovery research in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2499713-65-2
MW399.45
FormulaC22H21N7O
SMILESNC=1C2=C(N=C(N)N1)N=CC(CN(CC)C3=CC=C(C(=O)C4=CC=CC=C4)C=C3)=N2
TargetParasite,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information

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25 mg
$ 1,560.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
DispatchUsually dispatched within 6-8 weeks
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