Tebuconazole

SKU: orb1219127

Description

Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).

Images & Validation

−

Key Properties

−

CAS Number	107534-96-3
MW	307.82
Purity	>98% (HPLC)
Formula	C₁₆H₂₂ClN₃O
SMILES	CC(C)(C)C(CCc(cc1)ccc1Cl)(Cn1ncnc1)O
Target	P450
Solubility	DMSO:50 mg/mL (162.43 mM)

Bioactivity

−

In Vivo

Animal model: Male Wistar rats. Dosage: 10, 25, and 50 mg/kg. Administration: p.o. once daily for 28 days. Result: Induced CYP1A1/2, CYP2B1/2, CYP2E1, and CYP3A proteins in liver. Decreased glutathione content and increased glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase activities in liver. Increased superoxide dismutase activities in kidney and testis. Decreased glutathione S-transferase activity in testis. Decreased serum testosterone concentration and cauda epididymal sperm count. Animal model: Male and female Sprague-Dawley rats. Dosage: 25, 50, and 100 mg/kg. Administration: Oral gavage (p.o.), for 10 days. Result: Increased fetal serum testosterone and progesterone levels. Increased the number of fetal Leydig cells per testis without inducing cell aggregation. Up-regulated the expression levels of Star, Cyp11a1, Hsd17b3, and Fshr. Increased phosphorylation of AKT1, ERK1/2, and mTOR, the level of BCL2, as well as the decrease of Beclin1, LC3B, and BAX.

In Vitro

Western blot analysis. Cell line: HepG2 cells. Concentration: 20, 40, 80 μM. Incubation time: 1-12 hours. Result: Increased the nuclear translocation of peroxisome proliferator-activated receptors and the expression of cluster of differentiation 36, fatty acid transport protein (FATP) 2, FATP5, and carnitine palmitoyltransferase 1. Apoptosis Analysis Cell line: Bovine mammary gland epithelial cells (MAC-T cells. Concentration: 100, 150, 200, 250, 500, 750 μM. Incubation time: 24 hours. Result: Decreased cells viability and proliferation and activates apoptotic cell death via the upregulation of pro-apoptotic proteins, such as cleaved caspases 3 and 8 and BAX. Induced loss of mitochondrial membrane potential in MAC-T cells. Induced mitochondria-mediated apoptotic MAC-T cell death by activating ER stress. Induced endoplasmic reticulum (ER) stress via the upregulation of Bip/GRP78; PDI; ATF4; CHOP; and ERO1-Lα.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

P450

Protocol Information

Find More Protocols

Purity:	98.42% (May vary between batches)
CAS Number:	107534-96-3
MW:	307.82
Formula:	C₁₆H₂₂ClN₃O

Tebuconazole

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Similar Products

Tebuconazole-BSA conj. [orb3185666]

Tebuconazole-OVA conj. [orb3185581]

Tebuconazole-KLH conj. [orb3185751]

Tebuconazole [orb1307690]

Quality Guarantee

Quick Database Links

Protocol Information

Available Sizes

Email

UK Office

US Office

CN Office

Distributors