Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Tecadenoson

SKU: orb1307689

Description

Tecadenoson (CVT-510) is a selective A1 adenosine receptor agonist used in research. It has been investigated in vitro and in vivo for its potential cardioprotective effects, including applications in studies of heart rate regulation and myocardial ischemia.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number204512-90-3
MW337.33
Purity98.83% (May vary between batches)
FormulaC14H19N5O5
SMILESOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N[C@@H]3CCOC3)ncnc12
TargetAdenosine Receptor
SolubilityDMSO:155 mg/mL (459.49 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.82 mM)

Bioactivity

In Vivo
Intravenous infusions of Tecadenoson and diltiazem causes nearly equal prolongations of P-R interval In atrial-paced anaesthetized guinea-pigs. Tecadenoson (2, 5, 20 μg/kg i.p.) causes a rapid and sustained dose-dependent decrease in NEFA at doses that do not cause bradycardia. Tecadenoson (50 μg/kg) treatment induces a significant bradycardia (50% decrease in heart rate at 25 min) .
In Vitro
Tecadenoson is approximately 5 fold more potent to prolong the stimulus-to-His bundle (S-H interval), a measure of slowing AV nodal conduction (EC50=41 nM) than to increase coronary conductance (EC50=200 nM) in the atrial-paced isolated heart. Tecadenoson shortens atrial (EC50=73 nM) but not the ventricular monophasic action potentials (MAP). At concentrations of Tecadenoson (40 nM) and diltiazem (1 μM) that induces equal prolongation of S-H interval (~10 ms), diltiazem, but not Tecadenoson, significantly decreases left ventricular developed pressure (LVP) and markedly increases coronary conductance .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, CVT-510, CVT510, CVT 510, AdenosineReceptor, Adenosine Receptor, A1 adenosine receptor, A1, Tecadenoson, P1 receptor

Similar Products

  • Tecadenoson [orb1218502]

    >98% (HPLC)

    204512-90-3

    337.33

    C14H19N5O5

    10 mg, 25 mg, 2 mg, 1 g, 50 mg, 100 mg, 500 mg, 5 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 230.00
25 mg
$ 370.00
50 mg
$ 500.00
100 mg
$ 640.00
200 mg
$ 830.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry