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Tenalisib

SKU: orb1309019

Description

Tenalisib

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1639417-53-0
MW415.42
Purity99.71% (May vary between batches)
FormulaC23H18FN5O2
SMILESCC[C@H](Nc1ncnc2nc[nH]c12)c1oc2ccccc2c(=O)c1-c1cccc(F)c1
TargetPI3K
SolubilityDMSO:100 mg/mL (240.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.63 mM)

Bioactivity

Target IC50
PI3Kδ:25 nM|PI3Kγ:33 nM
In Vivo
Single agent(Tenalisib) activity is evident in difficult-to-treat subjects at ≥ 200 mg BID.
In Vitro
In both HEL-RS and HEL-RR cells, Tenalisib exhibits modest proliferation inhibition (33-46% inhibition @ 10 μM). Addition of 10 μM tenalisib to ruxolitinib is synergistic resulting in a near-complete inhibition of proliferation (>90% for HEL-RS and >70% for HEL-RR). Addition of 5 μM tenalisib, 4 h prior to the addition of ruxolitinib results in a significant reduction in EC50of ruxolitinib (5.8 μM) in HEL-RR cells.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, RP 6530, RP6530, RP-6530, Tenalisib, Phosphoinositide 3-kinase, PI3K, PI3Kγ, PI3Kδ

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  • Tenalisib (RP6530) [orb1220176]

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 210.00
50 mg
$ 310.00
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