Teprotumumab Antibody

SKU: orb1980716

Description

Teprotumumab is a human monoclonal antibody targeting the IGF-1 receptor's extracellular domain. It inhibits TSH and IGF-1 signaling in fibrocytes, reducing pro-inflammatory cytokine expression and Akt phosphorylation, making it a key research tool for studying thyroid-associated ophthalmopathy in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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Target	TSH Receptor,IGF-1R
Molecular Weight	145.62 kDa
Purity	99.60% (May vary between batches)
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Concentration	2.74 mg/mL
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Teprotumumab, TSH Receptor, TSHReceptor, R1507, R-1507, R 1507, HZN 001, HZN001, HZN-001, IGF-1R, IGF1R

Quality Guarantee

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Gene Symbol

TSH Receptor,IGF-1R

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