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Tetrahydropapaverine hydrochloride

SKU: orb1301202

Description

Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) is a neurotoxic tetrahydroisoquinoline alkaloid structurally related to salsolinol and tetrahydropapaveroline. It is used in neuroscience research to study selective dopaminergic neurotoxicity and mechanisms of Parkinson's disease in both in vitro and in vivo models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number6429-04-5
MW379.878
Purity99.08% (May vary between batches)
FormulaC20H26ClNO4
SMILESCl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC
TargetOthers,Hydroxylase
SolubilityDMSO:60 mg/mL (157.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.26 mM)

Bioactivity

Target IC50
TPH:5.7 μM
In Vivo
In mouse mastocytoma P815 cells involved in serotonin production, Tetrahydropapaverine can inhibit serotonin biosynthesis (IC50: 7.5 μM) and reduce tryptophan hydroxylase activity (IC50: 5.7 μM).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Norlaudanosine HCl, inhibit, Inhibitor, Tryptophan hydroxylase, Tetrahydroalkali hydrochloride, Tetrahydroalkali Hydrochloride, Tetrahydroisoquinolines, Tetrahydropapaverine, Tetrahydropapaverine HCl, Tetrahydropapaverine hydrochloride, Tetrahydropapaverine Hydrochloride
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 80.00
50 mg
$ 90.00
100 mg
$ 110.00
500 mg
$ 210.00
DispatchUsually dispatched within 3-5 working days
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