TGF-beta/Smad,NO Synthase,MMP Antibody

SKU: orb3032103

Description

KD014 (DX-2400) is a human monoclonal antibody (mAb) that targets MMP14, with a Ki of 0.9 nM. It inhibits TGFβ and SMAD2/3 signaling, increases macrophage count and iNOS expression, and shifts macrophage phenotype towards an antitumor M1-like type. KD014 exhibits antitumor activity in three tumor models (MDA-MB-231, MDA-MB-435, and PC3) and is applicable in breast cancer research.

Research Area

Immunology & Inflammation, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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Antibody Type	Inhibitor Antibody
Clonality	Monoclonal
Target	MMP,NO Synthase,TGF-beta/Smad
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

MMP,NO Synthase,TGF-beta/Smad

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