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TGF-β/Smad-IN-2

SKU: orb3173336

Description

TGF-β/Smad-IN-2 is an orally active TGF-β/Smad inhibitor. It suppresses TGF-β-induced differentiation of fibroblasts into myofibroblasts and collagen deposition, with an IC50 value of 102 μM for reducing collagen in LL29 cells. TGF-β/Smad-IN-2 acts by modulating the SMAD3/SMAD7 signaling pathway and decreases lung index in mice with pulmonary fibrosis. This compound is applicable in pulmonary fibrosis research.

Images & Validation

Key Properties

TargetTGF-beta/Smad

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information