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TH1760

SKU: orb1685551

Description

TH1760 (MKB) is a potent NUDT15 inhibitor (IC50=25 nM) that increases cellular 6-thio-(d)GTP incorporation, thereby sensitizing cells to 6-thioguanine. This compound enhances the anti-leukemic activity of thiopurines in research models, supporting its investigation in hematological malignancies.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number2567914-01-4
MW426.45
Purity97.03%
FormulaC20H18N4O5S
SMILESS(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3
TargetDNA/RNA Synthesis,Others,NUDIX hydrolase
SolubilityDMSO:1.8 mg/mL (4.22 mM)

Bioactivity

Target IC50
NUDT15:25 nM
In Vitro
TH1760 (0-100 µ M) maintained the thermal denaturation of NUDT15 in a dose-dependent manner. TH1760 (0, 5, 10, 20, and 50 µ M) increased the accumulation of thiopurine (6-TG) in a dose-dependent manner. TH1760 (10 µ M) increased the sensitivity of HCT116 and HCT116 3-6 cells to 6-TG. TH1760 has a higher sensitivity to BJ-RAS cells compared to BJ-hTERT cells. TH1760 (10 µ M; 16 h) promotes the accumulation and incorporation of 6-TG in HL-60 cells. TH1760 increased the expression of γ The expression of H2AX, caspase3, Cleared, and cPARP . TH1760 (0.05, 0.17, 0.55, and 1.8 µ M; 4 d) enhanced the anti-leukemia effect of 6-TG in a dose-dependent manner .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TH1760, TH-1760, TH 1760, NUDIX hydrolase, NUDIXhydrolase, NUDT15, MKB

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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TH1760 (orb1685551)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 1,170.00
10 mg
¥ 1,690.00
25 mg
¥ 3,250.00
50 mg
¥ 5,720.00
100 mg
¥ 8,320.00
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