Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

TH1834

SKU: orb3027322

Description

TH1834 is a selective small-molecule inhibitor of the Tip60/KAT5 histone acetyltransferase. It triggers DNA damage and apoptosis in breast cancer cells like MCF-7, while sparing the related MOF acetyltransferase, making it a useful research tool for studying chromatin biology and cancer mechanisms in vitro.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number2108830-08-4
MW568.71
Purity99.96% (May vary between batches)
FormulaC33H40N6O3
SMILESO=C(O)CN1N=NC(=N1)C2=CC=C(C=C2)CN(CCC=3C=CC=CC3)CCCCOC4=CC=C(C=C4)CN5CCCC5
TargetHistone Acetyltransferase,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.76 mM);DMSO:8 mg/mL (14.07 mM)

Bioactivity

In Vitro
TH1834, at concentrations ranging from 0 to 500 μM, acted on MCF7 cells for 1 hour, significantly reducing cell viability and enhancing cytotoxicity; at a concentration of 500 μM, it also activated caspase 3. In vitro experiments demonstrated that TH1834 exhibits significant inhibitory effects on Tip60 activity, resulting in apoptosis in breast cancer cells and an increase inunrepaired DNA damage.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TH1834, TH-1834, TH 1834

Similar Products

  • TH1834 dihydrochloride [orb1706544]

    2108830-09-5

    641.63

    C33H42Cl2N6O3

    50 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

TH1834 (orb3027322)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,430.00
5 mg
¥ 2,340.00
10 mg
¥ 3,640.00
25 mg
¥ 7,540.00
50 mg
¥ 13,000.00
100 mg
¥ 22,620.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry