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TLR7 agonist 29

SKU: orb2945067

Description

TLR7 agonist 29 (Compound 1) is a potent small molecule activator of human and mouse TLR7, with EC50 values of 5.2 nM and 48.2 nM, respectively. It induces immune activation in BMDMs and tumor myeloid cells, upregulating PD-L1, CD86, and IFN-α, and is suitable for use as an ADC payload in immunotherapy research.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery; Cell Biology

Images & Validation

Key Properties

MW397.47
FormulaC20H27N7O2
TargetADC Cytotoxin,PD-1/PD-L1,IFNAR,TLR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information