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Tofacitinib Prodrug-1

SKU: orb1744923

Description

Tofacitinib Prodrug-1 is an orally active prodrug designed to reduce the systemic side effects of tofacitinib. It has demonstrated efficacy in attenuating oxazolone-induced colitis in murine models, indicating its potential as a therapeutic candidate for ulcerative colitis. Its research applications include investigating prodrug strategies and JAK/STAT pathway inhibition in inflammatory bowel disease models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW759.21
FormulaC36H39ClN10O7
SMILESC[C@@H]1CCN(C(CC#N)=O)C[C@H]1CNC2=C3C=CN(C(N(CCCNC(OCC4=C(Cl)C=C(N=NC5=CC(C(O)=O)=C(O)C=C5)C=C4)=O)C)=O)C3=NC=N2
TargetJAK,Others,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information