Tofacitinib Prodrug-1

SKU: orb1744923

Description

Tofacitinib Prodrug-1 is an orally active prodrug designed to reduce the systemic side effects of tofacitinib. It has demonstrated efficacy in attenuating oxazolone-induced colitis in murine models, indicating its potential as a therapeutic candidate for ulcerative colitis. Its research applications include investigating prodrug strategies and JAK/STAT pathway inhibition in inflammatory bowel disease models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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MW	759.21
Formula	C₃₆H₃₉ClN₁₀O₇
SMILES	C[C@@H]1CCN(C(CC#N)=O)C[C@H]1CNC2=C3C=CN(C(N(CCCNC(OCC4=C(Cl)C=C(N=NC5=CC(C(O)=O)=C(O)C=C5)C=C4)=O)C)=O)C3=NC=N2
Target	Apoptosis,Others,JAK

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

163196450 ↗

Key Properties

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No computed properties available.

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