Topoisomerase IIα-IN-10

SKU: orb2945190

Description

TopoisomeraseIIα-IN-10 (Compound 13r) is a catalytic inhibitor that targets the Topo IIα-DNA complex, inducing apoptosis and loss of mitochondrial membrane potential in HCT116 cells with an IC50 of 4.37 µM. It is a useful chemical probe for cancer research, particularly in studies of cell proliferation and DNA damage response mechanisms in vitro.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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MW	501.575
Formula	C₃₂H₂₇N₃O₃
SMILES	CC(C)C1=CC=C(C=C1)C2=NC(=CC3=C2NC4=CC=CC=C43)CN=C(C)C5=C(C6=CC=CC=C6OC5=O)O
Target	Mitochondrial Metabolism,Apoptosis,Topoisomerase

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

172677018 ↗

Key Properties

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No computed properties available.

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