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trans-AUCB

SKU: orb1217535

Description

trans-AUCB is an effective and selective soluble epoxide hydrolase inhibitor (IC50s: 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively).

Images & Validation

Key Properties

CAS Number885012-33-9
MW412.52
Purity>98% (HPLC)
FormulaC24H32N2O4
SMILESO=C(O)C1=CC=C(O[C@H]2CC[C@H](NC(NC34CC5CC(C4)CC(C5)C3)=O)CC2)C=C1
TargetsEH
SolubilityDMSO:100 mg/mL (242.41 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Mice (male CFW strain, 7 weeks old, 24-30 g; and male C57BL/6 strain, 8 weeks old, 22-25 g). Dosage: 0.1, 0.5, 1 mg/kg. Administration: PO. Result: Ameliorated the LPS-induced hypotension in a dose-dependent manner. Animal model: Mice (male CFW strain, 7 weeks old, 24-30 g; and male C57BL/6 strain, 8 weeks old, 22-25 g). Dosage: 0.1, 0.5, 1 mg/kg (Pharmacokinetic Analysis). Administration: PO. Result: Had t1/2 values of 20, 30, 15 min and Cmax values of 30, 100, 150 nmol/L for p.o. of 0.1, 0.5, 1 mg/kg, respectively.
In Vitro
Cell Viability Assay Cell line: U251, U87 cells. Concentration: 25, 50, 100, 200, or 300 μM. Incubation time: 48 hours. Result: Suppressed U251 and U87 cell growth in a dose-dependent manner. Cell Cycle Analysis Cell line: U251, U87 cells. Concentration: 200 μM. Incubation time: 48 or 96 hours. Result: Induced cell-cycle G0/G1 phase arrest in U251 and U87 cells. Western blot analysis. Cell line: U251, U87 cells. Concentration: 200 μM. Incubation time: 10 min, 30 min, 1 hour, 2 hours, or 4 hours. Result: Increased the phosphorylation levels of p65 after 10 min, reached to peak after 30 min and lasted for at least 2 hours.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

t-AUCB

Similar Products

  • trans-AUCB [orb1307651]

    99.27% (May vary between batches)

    885012-33-9

    412.52

    C24H32N2O4

    5 mg, 1 mg, 50 mg, 1 ml x 10 mM (in DMSO), 10 mg, 25 mg
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trans-AUCB (orb1217535)

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% DMSO +
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% Tween 80 +
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100 mg
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2 mg
¥ 1,430.00
5 mg
¥ 2,080.00
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¥ 3,120.00