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TREM2 agonist-3

SKU: orb3135031

Description

TREM2 agonist-3 (Compound 4i) is a direct TREM2 agonist (Kd=19.0 µM), and its Kd value for TREM1 is 39.8 µM. It induces Syk phosphorylation and enhances microglial cell phagocytosis, and can be used for the study of neurodegenerative diseases.

Research Area

Neuroscience; Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW398.48
FormulaC21H22N2O4S
SMILESCNC(=O)C1=CC(C2=CC=C(S2)C(C)=O)=C(OC)C(NC(=O)C2CC(=C)C2)=C1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

Available Sizes

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1 mg
$ 440.00
DispatchUsually dispatched within 5-10 working days
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