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TREM2 agonist-5

SKU: orb3136489

Description

TREM2 agonist-5 is a ligand for the microglial lipid-sensing receptor (TREM2) and acts as an agonist with a Kd of 71.36 μM. It is the racemic analog of the TREM2 agonist VG-3927 and demonstrates excellent microglial phagocytic activity in HEK293-hTREM2/DAP12 cells, effectively activating TREM2 signaling. TREM2 agonist-5 has superior in vitro pharmacokinetics compared to VG-3927 and is potentially useful for Alzheimer's disease research.

Research Area

Neuroscience; Pharmacology & Drug Discovery

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Key Properties

TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

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25 mg
$ 1,710.00
50 mg
$ 2,220.00
100 mg
$ 2,840.00
DispatchUsually dispatched within 5-10 working days
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