Treprostinil

Name: Treprostinil
Brand: Biorbyt
SKU: orb1221185

SKU: orb1221185

Description

Treprostinil is a potent DP1 IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Research Area

Pharmacology & Drug Discovery

Images & Validation

−

Key Properties

−

CAS Number	81846-19-7
MW	390.51
Purity	>98% (HPLC)
Formula	C₂₃H₃₄O₅
SMILES	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@@H]2Cc3c(C[C@H]12)cccc3OCC(O)=O
Target	Prostaglandin Receptor
Solubility	DMSO: 40 mg/mL;Ethanol: 20 mg/mL

Bioactivity

−

In Vivo

Inhaled treprostinil sodium, a prostacyclin analog, is the most recent agent to receive FDA approval for the treatment of a fatal orphan disease: pulmonary arterial hypertension (PAH). Treprostinil preserves the sinusoidal endothelial cell lining and reduces platelet deposition early post-transplantation compared to placebo. Hepatic tissue blood flow is significantly compromised in the placebo group, whereas treprostinil maintains blood flow similar to normal levels. Treprostinil treatment significantly increases the vessel-forming ability of endothelial colony forming cells combined with mesenchymal stem cells in Matrigel implanted in nude mice. Silencing VEGF-A gene in mesenchymal stem cells also blocks the pro-angiogenic effect of Treprostinil. Treprostinil is most efficacious in raising intracellular cAMP levels in murine and human hematopoietic stem and progenitor cells. Treatment with Treprostinil significantly reduces the recruitment of cells compared to normoxic mice. Treprostinil also reduces right ventricular systolic pressure and slightly reduces the vascular remodelling but fails to reverse the right ventricular hypertrophy.

In Vitro

Treprostinil has high affinity for the DP1, EP2 and IP receptors (Ki=4.4, 3.6 and 32 nM, respectively), low affinity for EP1 and EP4 receptors and even lower affinity for EP3, FP and TP receptors. Activation of IP, DP1 and EP2 receptors, as with treprostinil, can all result in vasodilatation of human pulmonary arteries. Treprostinil inhibits viability of cultured endothelial colony forming cells. Endothelial colony forming cells proliferation is stimulated by conditioned media from Treprostinil pretreated mesenchymal stem cells.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

LRX-15 | Orenitram | Remodulin

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Quick Database Links

Gene Symbol

Prostaglandin Receptor

Protocol Information

Find More Protocols

CAS Number:	1706528-83-7
MW:	614.952
Formula:	C₃₉H₆₆O₅

Purity:	98.21% (May vary between batches)
CAS Number:	830354-48-8
MW:	495.65
Formula:	C₂₇H₄₅NO₇

Purity:	99.71% (May vary between batches)
CAS Number:	81846-19-7
MW:	390.51
Formula:	C₂₃H₃₄O₅

Treprostinil

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

15-Keto treprostinil sodium [orb3143661]

Treprostinil palmitil [orb3177656]

15-keto Treprostinil (sodium salt) [orb1693938]

Treprostinil diethanolamine [orb1686694]

Treprostinil [orb1302048]

Quality Guarantee

Quick Database Links

Protocol Information

Available Sizes

Email

UK Office

US Office

CN Office

Distributors