Tretazicar

SKU: orb1300455

Description

Tretazicar

Research Area

Metabolism Research, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	21919-05-1
MW	252.18
Purity	99.70%
Formula	C₉H₈N₄O₅
SMILES	NC(=O)c1cc(N2CC2)c(cc1[N+]([O-])=O)[N+]([O-])=O
Target	DNA Alkylator/Crosslinker,Reductase,DNA Alkylation
Solubility	Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:47 mg/mL (186.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM)

Bioactivity

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In Vivo	The NTR/CB1954 system, which is in a dose-dependent effect, are used for specific ablation of cells in vivo. NTR-mediated cell killing by CB1954, which is activated cross-links, presumed through triggers the apoptosis cascade resulting in rapid cell death. Selective and potent cells killing by NTR-CB1954 does not require a functional p53. Read more...
In Vitro	In the NPC cell line CNE1, toxic Tretazicar enhances cells killing. The overexpression of nitroreductase oxidored nitro domain-containing protein 1 (NOR1) reduce the 4 nitro group of Tretazicar, a potent cytotoxin, in order to convert the monofunctional alkylating agent Tretazicar into a toxic form. In the HepG2 cell line, the NOR1 gene upregulates of Grb2 expression and activates of MAPK signal transduction leading to enhances Tretazicar mediated cell cytotoxicity. Read more...
Cell Research	HepG2 cells,which are maintained in RPMI 1640 supplemented with 10% fetal calf serum (FCS) in a humidified culture incubator at 37 C with 5% CO2 and 95% air, grow to ~80% confluence are washed with PBS and treated with r CB1954(4-10 μmol/L) for 48hours. Read more...
Animal Research	RED 40 female mice,which express high levels of BLG-NTR transgene in the mammary gland and nontransgenic control mice on lactation day 6, were injected intraperitoneally （i.p.）with 50 mg/kg CB1954 dissolved in arachis oil containing 10% acetone. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CB1954, CB-1954, CB 1954, DNAAlkylator, DNAAlkylation, DNA, DNA Alkylator/Crosslinker, DNA Alkylator, DNA Alkylation, DNA alkylator, cross-link, Crosslinker, agent, 256, 4-hydroxylamine, 5-Aziridino-2,4-dinitrobenzamide, bifunctional, Inhibitor, inhibit, NSC115829, NSC-115829, NSC 115829, line, NQO1, rat, Walker, tumour, Tretazicar

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Compound Identifiers

PubChem CID

89105 ↗

Key Properties

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No computed properties available.

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CAS Number:	64881-21-6
MW:	181.19
Formula:	C₈H₁₁N₃O₂

Purity:	>98% (HPLC)
CAS Number:	21919-05-1
MW:	252.18
Formula:	C₉H₈N₄O₅

Tretazicar

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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