Triamcinolone acetonide

SKU: orb1310263

Description

Triamcinolone acetonide (Azmacort) is a synthetic glucocorticoid that acts as a corticosteroid receptor agonist, primarily used for its potent anti-inflammatory effects. It is widely applied in research models of dermatological, allergic, and autoimmune conditions, both in vitro for receptor studies and in vivo for evaluating anti-inflammatory efficacy.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	76-25-5
MW	434.50
Purity	99.91%
Formula	C₂₄H₃₁FO₆
SMILES	C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]
Target	FGFR,Glucocorticoid Receptor
Solubility	Ethanol:13 mg/mL (29.92 mM);DMSO:50 mg/mL (115.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.6 mM)

Bioactivity

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In Vivo

Triamcinolone Acetonide reduced polysaccharide synthesis and increased the glycosaminoglycan (GAG) content in the culture medium compared to the blank group and IL-1 group. It also augmented GAG degradation. This compound significantly decreased the paracellular permeability of ECV304 cells and downregulated ICAM-1 expression, corroborating with immunocytochemical observations. In rat retinas, Triamcinolone reversed Müller glial cell swelling, a phenomenon observed under various experimental conditions: in retinas isolated 3 days post-transient retinal ischemia, in control retinas with 1 mM Ba^2+, 10 μM arachidonic acid, 200 μM H2O2, or 30 nM prostaglandin E2, and in retinas with lipopolysaccharide-induced ocular inflammation.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, GlucocorticoidReceptor, Glucocorticoid Receptor, Azmacort, Aristoderm, Aristogel, Triamcinolone acetonide

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Compound Identifiers

PubChem CID

6436 ↗

Key Properties

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No computed properties available.

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