Tricin

SKU: orb1297574

Description

Tricin is a bioactive flavonoid that suppresses human cytomegalovirus (HCMV) replication through CDK9 inhibition. It also impedes glioma cell proliferation and invasion by upregulating microRNA-7, which targets focal adhesion kinase (FAK). This compound is a useful research tool for virology and oncology studies in vitro.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	520-32-1
MW	330.29
Purity	98.76%
Formula	C₁₇H₁₄O₇
SMILES	COc1cc(cc(OC)c1O)-c1cc(=O)c2c(O)cc(O)cc2o1
Target	CDK,Virus Protease
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.11 mM);DMSO:125 mg/mL (378.46 mM)

Bioactivity

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In Vitro

Methanol extract of Zizania latifolia was partitioned with EtOAc, n-BuOH, and H2O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, Tricin (1), salcolin A (2), salcolin B (3), and salcolin C (4), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be Tricin-4'-O-[erythro-β-guaiacyl-(7'-O-methyl)-glyceryl] ether and was named salcolin D (5) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2-5, Tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than Tricin. In particular, salcolin D (5) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as β-hexosaminidase release in IgE-sensitized RBL-2H3 cells

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, JNK, p38, Cytomegalovirus, CDK9, CMV, TLR, Tricin

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Compound Identifiers

PubChem CID

5281702 ↗

Key Properties

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No computed properties available.

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Tricin (orb1297574)

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Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

Applications:	ELISA, WB
Reactivity:	Plant
Species/Host:	Rabbit
Clonality:	Polyclonal
Conjugation:	Unconjugated

CAS Number:	32769-02-1
MW:	506.41
Formula:	C₂₃H₂₂O₁₃

CAS Number:	32769-00-9
MW:	492.43
Formula:	C₂₃H₂₄O₁₂

Purity:	99.23% (May vary between batches)
CAS Number:	32769-01-0
MW:	492.43
Formula:	C₂₃H₂₄O₁₂

Tricin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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