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TRPV1 antagonist 11

SKU: orb3027443

Description

TRPV1 antagonist 11 (compound 2ac) is a highly potent TRPV1 antagonist with an IC50 of 29.3 nM. It also acts as a μ-opioid receptor (MOR) agonist with a Ki of 60.3 nM. This pyrimidinylpiperazine compound provides analgesic effects by antagonizing TRPV1 and activating MOR. In mouse models of formalin-induced pain, TRPV1 antagonist 11 demonstrates effective dose-dependent antinociceptive properties.

Research Area

Metabolism Research, Neuroscience, Neuroscience; Pharmacology & Drug Discovery, Pharmacology & Drug Discovery

Images & Validation

Key Properties

FormulaC31H37N7O2
TargetTRP/TRPV Channel,Opioid Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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25 mg
$ 1,560.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
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