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TTNPB

SKU: orb1309111
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Description

TTNPB

Research Area

Cell Biology, Metabolism Research

Images & Validation

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TTNPB

Key Properties

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CAS Number71441-28-6
MW348.48
Purity99.55%
FormulaC24H28O2
SMILESCC(=Cc1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
TargetAutophagy,Retinoid Receptor,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:0.18 mg/mL (0.52 mM);DMSO:12.02 mg/mL (34.49 mM)

Bioactivity

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Target IC50
RARβ:4.5 nM|RARγ:9.3 nM|RARα:5.1 nM
In Vivo
After 72-hour cultivation in a conditioned medium, TTNPB increases the transcriptional activities of mouse mRARα (EC50: 2.0 nM), β (EC50: 1.1 nM), and γ (EC50: 0.8 nM) in JEG-3 cells. TTNPB exhibits high binding affinity to retinoic acid receptors, thereby inhibiting the binding of [3H]tRA to mRARα (IC50: 3.8 nM), β (IC50: 4.0 nM), and γ (IC50: 4.5 nM). TTNPB inhibits the growth of estrogen receptor-positive breast cancer cells and normal human mammary epithelial cells by inducing a G1 cell cycle arrest. Additionally, TTNPB concentration-dependently reduces the differentiation of ES-D3 cells.
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In Vitro
By inducing apoptosis, TTNPB (0.25 mg/kg) can inhibit the growth of the MXT-HI and MXT-HS models.
Cell Research
Human mammary epithelial cells are maintained in Mammary Epithelial Basal Medium (MEBM) supplemented with the Mammary Epithelial Growth Media (MEGM) bullet kit. 184 and 184B5 cells are maintained in MEBM sodium-bicarbonate free (MEBM-SBF) supplemented with the MEGM bullet kit, isoproterenol (10 μM), and transferrin (5 μg/ml). MCF10A cell lines are maintained in DME/F12 containing 5% heat inactivated horse serum, penicillin/streptomycin (100 μg/ml and 100 μg/ml), hydrocortisone (1.4 μM), insulin (10 μg/ml), choleratoxin (100 ng/ml), and EGF (20 ng/ml). Breast cancer cell lines are maintained in Improved MEM Zinc Option containing 10% fetal bovine serum, 1% glutamine, and 1% penicillin/streptomycin. For growth assays, cells are treated with the different retinoids for the specified number of days with media and treatment changes every other day in T47D cells and every 2 days in 184 cells. Cell proliferation is measured according to the protocol for the CellTiter 96 Aqueous Non-Radioactive Cell Proliferation Assay. This colorimetric assay determines the number of viable cells in a sample. Each point represents samples done in quadruplicate.(Only for Reference)
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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inhibit, Inhibitor, Apoptosis, Arotinoid acid, Autophagy, AGN 191183, AGN191183, AGN-191183, RARγ, RARβ, RARα, RAR/RXR, Retinoic acid receptors, Retinoid Receptor, Retinoid X receptors, RetinoidReceptor, Ro 13-7410, Ro 13-7410,AGN 191183, Ro 13-7410,AGN191183, Ro 13-7410,AGN-191183, TTNPB
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
5602 ↗

Key Properties

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No computed properties available.

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Protocol Information

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TTNPB (orb1309111)

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5 mg
¥ 2,600.00
25 mg
¥ 4,940.00
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