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Tyk2-IN-16

SKU: orb2565104

Description

Tyk2-IN-16 is a highly potent and selective TYK2 pseudokinase (JH2) domain inhibitor, demonstrating sub-10 nM IC50 values against both the isolated domain and pSTAT4 in NK92 cells. This tool compound is valuable for investigating TYK2-mediated signaling in autoimmune and inflammatory disease research, as evidenced in the patent literature.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number3010874-30-0
MW426.42
FormulaC20H20F2N8O
SMILESN(C(C)=O)C=1C=C2C(C(=NN2C=3N=C(C(C)(F)F)C=CN3)N4CC(C#N)(C)CC4)=CN1
TargetJAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information