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Tyk2-IN-22

SKU: orb2814223

Description

Tyk2-IN-22 (Compound A8) is a potent and selective Tyk2 inhibitor with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM for Tyk2, JAK1, and JAK3, respectively, and it suppresses STAT5 phosphorylation. This small molecule is a valuable research tool for investigating JAK-STAT signaling pathways in autoimmune and inflammatory disease models, both in vitro and in vivo.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number933667-23-3
MW345.78
FormulaC16H16ClN5O2
SMILESO=C1C=C(N=C2NC(=NN12)C=3C=CC(Cl)=CC3)CN4CCOCC4
TargetJAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

Tyk2-IN-22 (orb2814223)

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