UK-101

SKU: orb1708295

Description

UK-101 is a potent, selective immunoproteasome inhibitor targeting the LMP2 (β1i) subunit with high affinity, inducing apoptosis in prostate cancer models. It is a valuable research tool for studying immunoproteasome function in oncogenesis and has been utilized in both in vitro and in vivo experimental studies of cancer cell death mechanisms.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

−

Key Properties

−

CAS Number	1000313-40-5
MW	484.74
Purity	>99.99% (May vary between batches)
Formula	C₂₅H₄₈N₂O₅Si
SMILES	C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1
Target	Apoptosis,Proteasome
Solubility	DMSO:237.5 mg/mL (489.95 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.81 mM)

Bioactivity

−

Target IC50	Immunoproteasome β1c:15 μM\|LMP2:104 nM\|Immunoproteasome β5:1 μM
In Vivo	Tumor volume as a dose-dependent manner decreased by UK-101 (1-3 mg/kg; twice a week; 3 weeks)intraperitoneal injection, it significantly decreases tumor volume at a dose of 3 mg/kg. Additionally, UK-101-treated mice are suffering less systemic toxicity and the weights of mice treated with UK-101 remain steady over the 3-week treatment period. Read more...
In Vitro	In the G1 phase of the cell cycle, UK-101 (2-8 μM; 24 hours) induces cell cycle arrest and increases the number of the PC-3 cell arrest.UK-101 (1-8 μM; 24 hours) induces cell accumulation in the G1 phase of the cell cycle, it increases p27 accumulation and significantly increases PARP cleavage as a dose-dependent manner. Read more...

Storage & Handling

−

Storage	Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

immunoproteasome β1c, immunoproteasome β5, LMP2, UK101, UK-101, UK 101

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID

24752894 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

UK-101 (orb1708295)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

UK-101

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

UK-101 (orb1708295)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors