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UNC2881

SKU: orb1305245

Description

UNC2881 is a potent and selective small molecule inhibitor of Mer tyrosine kinase (MERTK), exhibiting an IC50 of 4.3 nM with 83-fold and 58-fold selectivity over Axl and Tyro3, respectively. This inhibitor is a valuable research tool for studying MERTK signaling in oncology and immunology, applicable in both in vitro cellular assays and in vivo model systems.

Research Area

Infectious Disease & Virology, Signal Transduction

Images & Validation

Key Properties

CAS Number1493764-08-1
MW463.58
Purity99.72% (May vary between batches)
FormulaC25H33N7O2
SMILESCCCCNc1ncc(C(=O)NCc2ccc(cc2)-n2ccnc2)c(NC2CCC(O)CC2)n1
TargetTAM Receptor
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.12 mM);DMSO:85 mg/mL (183.36 mM);Ethanol:5 mg/mL (10.79 mM)

Bioactivity

Target IC50
Mer:4.3 nM
In Vivo
UNC2881 inhibits the activity of Mer kinase in 697 B-ALL cells (IC50: 22 nM) and suppresses collagen-stimulated platelet aggregation.
In Vitro
In mice, UNC2881 exhibits a high total clearance rate (94.5 ml/kg/min), with an oral bioavailability of 14%.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Axl, AXL, Mer, Inhibitor, inhibit, pathologic thrombosis, orally active, platelet aggregation, TAM Receptor, TAMReceptor, phosphorylation, Tyro3, UNC2881, UNC-2881, UNC 2881

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  • UNC2881 [orb1223282]

    >98% (HPLC)

    1493764-08-1

    463.58

    C25H33N7O2

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 110.00
25 mg
$ 170.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 520.00
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