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UNI418

SKU: orb2665382

Description

UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).

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Key Properties

CAS Number1802068-51-4
MW364.40
FormulaC22H16N6
SMILESN=1C=CC(=CC1)C2=NC3=CC=CC=C3C(=N2)NC4=NNC(=C4)C=5C=CC=CC5
TargetSARS-CoV

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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UNI418 (orb2665382)

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