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Val-Ala-PAB-MMAE

SKU: orb2279056

Description

Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number1912408-92-4
MW1037.33
Purity99.02%
FormulaC55H88N8O11
SMILES[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
TargetDrug-Linker Conjugates for ADC,Microtubule Associated
SolubilityDMSO:80 mg/mL (77.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (3.18 mM)

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
DisclaimerFor research use only

Alternative Names

DrugLinkerConjugatesforADC, DrugLinker Conjugates for ADC
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Val-Ala-PAB-MMAE (orb2279056)

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1 mg
¥ 1,170.00
5 mg
¥ 1,950.00
10 mg
¥ 2,860.00
25 mg
¥ 4,810.00
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