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VAS 3947

SKU: orb1699022

Description

VAS 3947

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Images & Validation

Key Properties

CAS Number869853-70-3
MW310.33
Purity99.25%
FormulaC14H10N6OS
SMILESC(c1ccccc1)n1nnc2c(Sc3ncco3)ncnc12
TargetNADPH,NADPH-oxidase,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.63 mM);DMSO:90 mg/mL (290.01 mM)

Bioactivity

Target IC50
MV-4-11 cells:2.6±0.6µM|THP-1 cells:4.9µM|ROS:12 µM
In Vitro
VAS 3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins. VAS 3947 (30 µM) does not interfere with xanthine/XOD-derived L012 signals, suggesting this compound is free of antioxidant or scavenging effects relevant to ROS detection. VAS 3947 attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC3.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, NOX, NADPHoxidase, VAS3947, VA-S3947, VA-S-3947, VAS-3947, VAS 3947, VA-S 3947, VA S 3947, VA S3947, VA S-3947
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

VAS 3947 (orb1699022)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,820.00
1 ml x 10 mM (in DMSO)
¥ 1,950.00
10 mg
¥ 2,860.00
25 mg
¥ 4,680.00
50 mg
¥ 6,370.00
100 mg
¥ 8,320.00
200 mg
¥ 10,790.00
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