VBIT-4

SKU: orb1708263

Description

VBIT-4 is a small molecule inhibitor of VDAC1 oligomerization with a Kd of 17 µM. It is a research tool for studying apoptosis in models of neurodegenerative and cardiovascular diseases, showing therapeutic potential in both in vitro and in vivo experimental systems.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2086257-77-2
MW	457.87
Purity	99.93% (May vary between batches)
Formula	C₂₁H₂₃ClF₃N₃O₃
SMILES	C(CC(NC1=CC=C(Cl)C=C1)=O)(CO)N2CCN(CC2)C3=CC=C(OC(F)(F)F)C=C3
Target	VDAC
Solubility	DMSO:245 mg/mL (535.09 mM);5% DMSO+40% PEG300+5% Tween 80+50% Saline:2 mg/mL (4.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.5 mg/mL (9.83 mM)

Bioactivity

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Target IC50	HEK293 cells:2.9 µM\|VDAC1:17 Μm (kd)\|VDAC1:1.9 ± 0.08 μM\|Cytochrome c:1.8 ± 0.24 μM
In Vivo	METHODS: To test the effect on Alzheimer's disease, VBIT-4 (25 mg/kg) was injected intraperitoneally into APP/PS1 mice once daily for four weeks. RESULTS: VDAC1 was significantly up-regulated in APP/PS1 mice and decreased after VBIT-4 treatment; GPX4 expression was decreased in APP/PS1 mice and restored by VBIT-4 treatment; MWM test showed that APP/PS1 mice had a longer latency to find the plateau; VBIT-4 treatment significantly decreased the latency to find the plateau in APP/PS1 mice. VBIT-4 treatment significantly reduced the latency of platform finding in APP/PS1 mice. Read more...
In Vitro	VBIT-4 targets the mitochondrial protein VDAC1, inhibits apoptosis and defends against mitochondrial dysfunction. VBIT-4 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis (in HEK-293 cells , IC50s of 1.9±0.08 μM, 1.8±0.24 μM, and 2.9±0.12 μM, respectively).VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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VBIT 4, VBIT4, VBIT-4, VDAC1

Quality Guarantee

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Compound Identifiers

PubChem CID

126697666 ↗

Key Properties

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No computed properties available.

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VBIT-4

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

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Protocol Information

VBIT-4 (orb1708263)

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