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Vidofludimus

SKU: orb1305278

Description

Vidofludimus (SC12267) is a potent and selective small molecule inhibitor of dihydroorotate dehydrogenase (DHODH). It has demonstrated efficacy in preclinical models of autoimmune diseases, such as multiple sclerosis and lupus, through both in vitro enzymatic assays and in vivo studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology

Images & Validation

Key Properties

CAS Number717824-30-1
MW355.36
Purity99.58% (May vary between batches)
FormulaC20H18FNO4
SMILESCOc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1
TargetDNA/RNA Synthesis,FXR,Dehydrogenase,Interleukin
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:3.3 mg/mL (9.29 mM);DMSO:100 mg/mL (281.4 mM);Ethanol:1 mg/mL (2.81 mM)

Bioactivity

Target IC50
DHODH (human):134 nM
In Vivo
In MRLlpr/lpr mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis. In Rats, Vidofludimus (60 mg/kg, p.o.) effectively reduces macroscopic and histological pathology and the numbers of CD3+ T cells. In a rat model of renal transplantation, Vidofludimus (20 mg/kg, p.o.) prolongs survival, paralleled by amelioration of histologic signs of acute rejection.
In Vitro
Vidofludimus causes a concentration dependent inhibition of phytohemagglutinin-stimulated PBMC proliferation via the inhibition of pyrimidine de novo synthesis. Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

RNA Synthesis, RNASynthesis, SC 12267, SC12267, SC-12267, Vidofludimus, 4sc-101, DHODH, Dihydroorotate Dehydrogenase, DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, dihydroorotate dehydrogenase (DHODH), Inhibitor, Interleukin Related, Interleukin, farnesoid X receptor (FXR), fatty liver, Human DHODH, FXR, immunomodulatory, inflammatory bowel disease (IBD), NR1H4, inhibit, non-alcoholic fatty liver disease (NAFLD), oral

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Key Properties

No computed properties available.

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Protocol Information

Vidofludimus (orb1305278)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
5 mg
¥ 1,560.00
10 mg
¥ 2,210.00
25 mg
¥ 3,510.00
50 mg
¥ 5,330.00
100 mg
¥ 7,410.00
DispatchUsually dispatched within 3-5 working days
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