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Voglibose

SKU: orb1300524

Description

Voglibose

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Voglibose

Key Properties

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CAS Number83480-29-9
MW267.28
Purity99.84% (May vary between batches)
FormulaC10H21NO7
SMILESN(C(CO)CO)[C@H]1C[C@@](CO)(O)[C@@H](O)[C@H](O)[C@H]1O
TargetGlucosidase
SolubilityH2O:26.7 mg/mL (99.9 mM);DMSO:45 mg/mL (168.36 mM)

Bioactivity

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In Vivo
Voglibose (0.2 mg/kg) completely inhibits the insulin response to sucrose in rats. Voglibose (0.2 mg/kg) reduces the carbohydrate-induced increase in blood glucose in rats. Voglibose (0.2 mg/kg) reduces the carbohydrate-induced increase in blood glucose without causing sustained hypoglycemia in both normal and neonatal streptozotocin-induced diabetic rats. Voglibose (0.001%) treatment increases GLP-1 secretion (Voglibose alone, 1.6-fold; Alogliptin plus Voglibose, 1.5-fold), while it decreases plasma glucose-dependent insulinotropic polypeptide (GIP) (Voglibose alone, 30%; Alogliptin plus voglibose, 29%) in prediabetic db/db mice after 3 weeks. Voglibose (0.001%) treatment decreases plasma DPP-4 activity by 15% in prediabetic db/db mice. Voglibose (0.001%) treatment increases plasma insulin by 1.8-fold and decreases plasma glucagon by 8% in prediabetic db/db mice. Voglibose (0.001% and 0.005%) stimulates GLP-1 secretion in ob/ob mice, as evidenced by the 1.3- to 1.5-fold increase in plasma active plus inactive amidated GLP-1 levels. Voglibose (0.001% and 0.005%) decreases plasma DPP-4 activity unexpectedly by 40% to 51% in ob/ob mice, resulting from reduced plasma DPP-4 concentrations. Voglibose (0.001% and 0.005%) increases GLP-1 content by 1.5- to 1.6-fold and 1.4- to 1.6-fold in the lower intestine and colon, respectively, in ob/ob mice.
In Vitro
Voglibose can inhibit the intestinal α-glucosidases, which are responsible for the digestion of disaccharides such as maltose and sucrose, including maltase and sucrase. The Ki values of Voglibose for sucrase and maltase are about 106and 105 times smaller than the Km values for sucrose and maltose.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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AO 128, AO128, AO-128, Basen, inhibit, Glustat, Glucosidase, Inhibitor, α-glucosidase, Voglibose

Similar Products

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  • Voglibose [orb1221743]

    >98% (HPLC)

    83480-29-9

    267.28

    C10H21NO7

    25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
Quality Guarantee

Quality Guarantee

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Compound Identifiers

PubChem CID
444020 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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10 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 90.00
50 mg
$ 110.00
100 mg
$ 140.00
200 mg
$ 190.00
500 mg
$ 290.00
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