Vopratelimab Antibody

SKU: orb1944780

Description

Vopratelimab is a humanized monoclonal IgG1 antibody that acts as a potent and selective ICOS agonist with high affinity across species. It exhibits anti-tumor immune activity and has been investigated in preclinical and clinical research for applications in oncology, including metastatic non-small cell lung cancer.

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Key Properties

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CAS Number	2039148-04-2
MW	145.74 kDa
Purity	98.34% (SEC-HPLC)
Target	Others

Bioactivity

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In Vivo	Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; twice weekly for 2 weeks) induces tumor regression in the Sa1/N syngeneic mouse tumor model.
In Vitro	Vopratelimab (JTX-2011; 0.001-10 μg/mL; 3 days; CD4 T cells) activates primary human T cells, inducing the secretion of IFNγ, IL-17a, IL-10, IL-9, GM-CSF, TNFα, and IL-21. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Vopratelimab, JTX 2011, JTX2011, JTX-2011, ICOS

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