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Vorasidenib

SKU: orb1299935

Description

Vorasidenib is a potent and selective small molecule inhibitor of mutant IDH1 and IDH2 enzymes, with IC50 values of approximately 32 nM. It is a valuable research tool for investigating oncogenic metabolism in cancers like glioma and cholangiocarcinoma, both in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1644545-52-7
MW414.7
Purity>98%
FormulaC14H13ClF6N6
SMILESC[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F
TargetDehydrogenase (GAPDH, GPDH, IMPDH, PHGDH, LDH, DHODH, ALDH, GDH, IDH, UGDH, DPD, DHPDH, KGDH, PDH, and MDH)
SolubilitySoluble in DMSO (up to 25 mg/ml)

Bioactivity

Target IC50
IDH1 (R132H):31.9 nM |IDH2 (R140Q):31.7 nM
In Vivo
Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AG-881

Similar Products

  • Vorasidenib [orb1225999]

    >98% (HPLC)

    1644545-52-7

    414.74

    C14H13ClF6N6

    500 mg, 200 mg, 2 mg, 10 mg, 25 mg, 50 mg, 5 mg, 100 mg, 1 g
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Key Properties

No computed properties available.

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Vorasidenib (orb1299935)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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5 mg
¥ 2,730.00
25 mg
¥ 5,850.00
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