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WAY-262611

SKU: orb1306922

Description

WAY-262611

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1123231-07-1
MW318.42
Purity99.27%
FormulaC20H22N4
SMILESNCC1CCN(CC1)c1nccc(n1)-c1ccc2ccccc2c1
TargetWnt/beta-catenin
SolubilityDMSO:42 mg/mL (131.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.14 mM)

Bioactivity

Target IC50
β-catenin (TCF-Luciferase assay):0.63 μM
In Vivo
WAY-262611 exhibits exceptional pharmacokinetic properties and, upon oral administration, demonstrates a dose-dependent increase in trabecular bone formation in ovariectomized rats. Calvariae from wild-type mice treated with WAY-262611 display significantly increased bone formation rates (BFR), whereas knockout (KO) animals treated in the same manner show no difference from control, suggesting that WAY-262611 operates through the Wnt β-catenin pathway, likely via inhibition of Dkk-1.
In Vitro
WAY-262611 demonstrates the highest potency, low kinase inhibition potential, and high solubility in the primary assay .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

beta-catenin, betacatenin, Beta catenin, bcatenin, Inhibitor, inhibit, WAY 262611, Wnt/b-catenin, Wnt/betacatenin, Wnt, WAY262611, WAY-262611, Wnt/β-catenin, β-catenin, βcatenin

Similar Products

  • WAY-262611 [orb1226962]

    >98% (HPLC)

    1123231-07-1

    318.4

    C20H22N4

    1 g, 500 mg, 200 mg, 25 mg, 5 mg, 10 mg, 50 mg, 100 mg
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Key Properties

No computed properties available.

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WAY-262611 (orb1306922)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
¥ 1,300.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
10 mg
¥ 1,690.00
25 mg
¥ 2,860.00
50 mg
¥ 4,810.00
100 mg
¥ 7,020.00
DispatchUsually dispatched within 3-5 working days
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