Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

WCF-598

SKU: orb3211295

Description

WCF-598 is a RXRγ degrader (Kd: 234.2 nM) and an AR-V7 PROTAC degrader. It induces RXRγ degradation through the ubiquitin-proteasome pathway and can bind directly to RXRγ. Additionally, WCF-598 indirectly induces AR-V7 degradation by destabilizing the RXRγ-AR-V7 complex, reducing AR-V7 levels, and inhibiting the transcription of AR-V7 downstream target genes. It promotes tumor cell apoptosis, inhibits cell proliferation, activates the p53 signaling pathway, and impedes cell cycle progression. WCF-598 is applicable in prostate cancer research.

Images & Validation

Key Properties

CAS Number3059574-58-9
MW894.11
FormulaC54H63N5O7
SMILESO=C(O)C=1C=CC(=CC1)C2=NC3=CC(=CC=C3N(C=4C=C5C(=CC24)C(C)(C)CCC5(C)C)C)NC(=O)CCCCCCCCCCCOC6=CC=CC=7C(=O)N(CC67)C8C(=O)NC(=O)CC8
TargetRetinoid Receptor,Androgen Receptor,PROTACs,MDM-2/p53,Apoptosis,Caspase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information