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WH244

SKU: orb2564594

Description

WH244 is a potent and selective PROTAC degrader of BCL-2 and BCL-xL, with DC50 values of 7.4 nM and 0.6 nM, respectively. It induces target ubiquitination and proteasomal degradation, restoring apoptosis and demonstrating antitumor efficacy in cellular and in vivo cancer research models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2941088-96-4
MW1681.51
FormulaC83H105ClF3N13O11S4
SMILESC(C1=C(CC[C@](CN2CCN(C(CN3CCN(CC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)CC3)=O)CC2)(C)C1)C7=CC=C(Cl)C=C7)N8CCN(CC8)C9=CC=C(C(NS(=O)(=O)C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN%11[C@@]%12(C[C@](C%11)(OC%12)[H])[H])CSC%13=CC=CC=C%13)C=C%10)=O)C=C9
TargetPROTACs,Apoptosis,Bcl-2 Family

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

WH244 (orb2564594)

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