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WYC209

SKU: orb1221041

Description

WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).

Images & Validation

Key Properties

CAS Number2131803-90-0
MW368.45
Purity>98% (HPLC)
FormulaC20H20N2O3S
SMILESCCOC(=O)c1cnc(nc1)C#Cc1ccc2c(c1)C(C)(C)CCS2=O
TargetRetinoid Receptor
SolubilityDMSO: 80 mg/mL (217.13 mM);Water: Insoluble

Bioactivity

In Vivo
WYC-209 (0.022-0.22 mg/kg; i. v. ; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases. Animal model: Female immune-competent C57BL/6 mice. Dosage: 0.022, 0.22 mg/kg. Administration: Intravenous injection; once every two days for 25 days. Result: Four out of eight mice formed lung metastases at dose of 0.022 mg /kg, only one out of eight mice formed lung metastases at dose of 0.22 mg/kg.
In Vitro
WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect. Apoptosis Analysis Cell line: A2780, A549, MCF-7, MDA-MB-435s, A375 cells. Concentration: 10 μM. Incubation time: 24 hours. Result: TRCs failed to resume growth 5 days after the drug washout.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • WYC-209 [orb1301872]

    98.91% (May vary between batches)

    2131803-90-0

    368.45

    C20H20N2O3S

    5 mg, 10 mg, 50 mg, 100 mg, 25 mg
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Protocol Information

WYC209 (orb1221041)

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% DMSO +
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% Tween 80 +
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Available Sizes

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200 mg
500 mg
5 mg
¥ 1,300.00
10 mg
¥ 1,950.00
25 mg
¥ 3,510.00
50 mg
¥ 5,330.00
100 mg
¥ 8,450.00