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XL44

SKU: orb2565045

Description

XL44 is a small molecule that binds hRpn13, inducing hRpn13-dependent apoptosis and reducing cell viability through a PCLAF-mediated mechanism. It promotes ubiquitin-dependent degradation of the hRpn13 Pru domain and ubiquitin-independent degradation of specific KEN box proteins. This compound is a valuable research tool for studying proteasome regulation, cell death pathways, and targeted protein degradation in both cellular and biochemical assays.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number2637949-91-6
MW388.39
FormulaC23H17FN2O3
SMILESC(=C1C=2C(NC1=O)=CC=C(F)C2)C3=CC(NC(=O)C4=CC=C(OC)C=C4)=CC=C3
TargetApoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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XL44 (orb2565045)

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