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XRF-1021

SKU: orb3174559

Description

XRF-1021 is an orally active HIPK2 inhibitor with an IC50 value of 0.18 μM. It reduces the expression of fibrosis markers such as fibronectin, type I collagen, and α-SMA in NRK-49F and HK-2 cells stimulated by TGF-β1. XRF-1021 blocks signaling pathways including TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch. Additionally, it alleviates renal injury and fibrosis in vivo and can be utilized for research in chronic kidney disease.

Images & Validation

Key Properties

CAS Number2968523-32-0
MW404.45
FormulaC21H21FN8
SMILESFC1=CN=C(N=C1NC2=CC=C(C=C2)N3CCNCC3)N4C(=NC=5C=CC=CC54)N
TargetNF-κB,Wnt/beta-catenin,MDM-2/p53,TGF-beta/Smad,DYRK,Gamma-secretase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information