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YNT-185

SKU: orb1691470

Description

YNT-185 is a potent and selective nonpeptide agonist for the orexin-2 receptor (OX2R), with an EC50 of 0.028 μM, showing over 98-fold selectivity over OX1R. It has demonstrated efficacy in alleviating narcolepsy-cataplexy symptoms in mouse models, making it a valuable tool for in vivo sleep/wake regulation research and in vitro OX2R signaling studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1804978-81-1
MW615.74
Purity99.67%
FormulaC33H37N5O5S
SMILESS(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4
TargetOX Receptor
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (4.06 mM);DMSO:62 mg/mL (100.69 mM);H2O:Insoluble

Bioactivity

Target IC50
OX2 recepter:0.028(EC50)|OX1 receptor:2.75 μM(EC50)
In Vivo
YNT-185 (20-40 mg/kg; i.p.) enhances alertness in mice. In a dose-dependent manner, YNT-185 (300 nmol; i.c.v.) significantly extends wakefulness for 3 hours and reduces non-rapid eye movement (NREM) sleep duration in wild-type mice but not in OXRDKO mice.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

OX2, OX Receptor, OXReceptor, YNT 185, YNT185, YNT-185

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Key Properties

No computed properties available.

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YNT-185 (orb1691470)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 1,300.00
5 mg
¥ 2,470.00
10 mg
¥ 3,640.00
25 mg
¥ 6,760.00
50 mg
¥ 10,660.00
100 mg
¥ 14,170.00
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