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Z-LEHD-fmk

SKU: orb1945049

Description

Z-LEHD-FMK is a potent and selective caspase-9 inhibitor with demonstrated protective effects in models of reperfusion injury and apoptosis. Its applications span oncology, neuroprotection, and embryology, where it has shown antitumor activity, neuroprotective properties, and the ability to improve embryo yield in in vitro bovine embryo production studies.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number210345-04-3
MW690.72
Purity96.13% (May vary between batches)
FormulaC32H43FN6O10
SMILESCOC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
TargetApoptosis,Caspase
SolubilityDMSO:90 mg/mL (130.3 mM)

Bioactivity

In Vivo
In spinal cord injury (SCI) rats, Z-LEHD-FMK administered intravenously at a dose of 0.8 μmol/kg for 7 days protects neurons, glia, myelin, axons, and intracellular organelles.
In Vitro
Pretreated for 30 minutes at a concentration of 20 μM, Z-LEHD-FMK completely protects HCT116 and 293 cells from TRAIL-induced toxicity. Additionally, at a concentration of 20 μM for 6 hours, Z-LEHD-FMK protects normal human hepatocytes from TRAIL-induced apoptosis.

Storage & Handling

Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Caspase-9, Apoptosis, Z LEHD FMK, ZLEHDFMK

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Z-LEHD-fmk (orb1945049)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
¥ 3,120.00
5 mg
¥ 8,580.00
10 mg
¥ 11,960.00
25 mg
¥ 17,160.00
50 mg
¥ 23,270.00
DispatchUsually dispatched within 3-5 working days
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