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Zharp1-211

SKU: orb2565025

Description

Zharp1-211 is a potent and selective RIPK3 inhibitor. It suppresses JAK/STAT1-driven chemokine and MHC class II expression in intestinal epithelial cells, demonstrating efficacy in models of gastrointestinal inflammation and graft-versus-host disease (GVHD) by restoring intestinal homeostasis.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2258671-41-7
MW447.49
Purity99.71%
FormulaC24H25N5O4
SMILESO=C(OC1CCOCC1)N2C=3C=C(C=NC3CC2)C=4C=CC5=NC(=CN5C4)NC(=O)C6CC6
TargetRIP kinase,STAT
SolubilityDMSO:8 mg/mL (17.88 mM)

Bioactivity

In Vivo
Oral administration of Zharp1-211 (10 mg/kg) starting on day 7 after T cell transplantation significantly reduced GVHD severity and improved survival in multiple mouse models. Zharp-211 alleviated inflammation in the colon, small intestine, liver, and skin, preserved intestinal stem and Paneth cells, suppressed chemokine expression, reduced alloreactive T and CXCR3⁺ T cells, and inhibited STAT1 activation and necroptosis/apoptosis in the gut.
In Vitro
Zharp1-211 was highly potent for blocking TNF-induced necroptosis in human colon cancer HT-29 cells and mouse fibroblast L929 cells, and reduced IFN-γ–induced STAT1 activation in mouse intestinal crypt cells by affecting the JAK1/STAT1 pathway.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Zharp1211
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Zharp1-211 (orb2565025)

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Available Sizes

Select a size below

1 mg
¥ 1,690.00
5 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 3,380.00
10 mg
¥ 4,810.00
25 mg
¥ 8,710.00
50 mg
¥ 13,130.00
100 mg
¥ 19,370.00
200 mg
¥ 25,870.00
DispatchUsually dispatched within 5-10 working days
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