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ZM39923 hydrochloride

SKU: orb1301036

Description

ZM39923 hydrochloride is a selective JAK1 and JAK3 inhibitor with pIC50 values of 4.4 and 7.1, respectively, exhibiting minimal activity against JAK2 and moderate potency toward EGFR. This compound has been utilized in vitro to investigate JAK/STAT signaling pathways in immunology and oncology research, and it is also noted as a substrate for transglutaminase.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1021868-92-7
MW367.91
Purity98.05% (May vary between batches)
FormulaC23H25NO·HCl
SMILESCl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1
TargetJAK|||EGFR
SolubilityDMSO:28 mg/mL (76.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM);Ethanol:8 mg/mL (21.74 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
JAK3:7.1 (pIC50)|CDK4:5.0 (pIC50)|JAK1:4.4 (pIC50)|EGFR:5.6 (pIC50)|TGase 2:10 nM|Lck:5.0 (pIC50)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, JAK1, JAK, Janus kinase, JAK3 Inhibitor IV, JAK3, EGFR, Inhibitor, ZM 39923, ZM 39923 HCl, ZM 39923 Hydrochloride, TGM2, ZM39923, ZM-39923, ZM39923 hydrochloride, ZM39923 Hydrochloride, ZM-39923 hydrochloride, ZM-39923 Hydrochloride

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 220.00
50 mg
$ 370.00
100 mg
$ 500.00
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