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1V209

SKU: orb1299043

Description

1V209 (T7) is a small molecule agonist of Toll-like receptor 7 (TLR7) with demonstrated anti-tumor properties. It is utilized in immunological and oncology research to stimulate innate immune responses, showing activity in both in vitro cellular assays and in vivo tumor model studies.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1062444-54-5
MW359.34
Purity99.61% (May vary between batches)
FormulaC16H17N5O5
SMILESCOCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(cc3)C(O)=O)c2n1
TargetTLR
SolubilityDMSO:83.33 mg/mL (231.9 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.18 mM)

Bioactivity

In Vivo
In the in vivo immunization study, 1V209-αMan-GNPs induced significantly higher titers of IgG2c antibody specific to ovalbumin as an antigen than did unconjugated 1V209, and splenomegaly and weight loss were not observed.
In Vitro
The small molecule synthetic TLR7 ligand, 2-methoxyethoxy-8-oxo-9-(4-carboxy benzyl)adenine (1V209), and α-mannose were coimmobilized via linker molecules consisting of thioctic acid on the GNP surface (1V209-αMan-GNPs). The in vitro cytokine production activity of 1V209-αMan-GNPs was higher than that of the unconjugated 1V209 derivative in mouse bone marrow-derived dendritic cells and in human peripheral blood mononuclear cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

conjugate, cell, 1V 209, 1V209, 1V-209, cancer, inhibit, IP-10, intravenous, IL-6, Inhibitor, MCP-1, polysaccharides, TLR7 agonist T7, TLR7, TLR, Toll-like Receptor (TLR), TNFα, Tumor
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Key Properties

No computed properties available.

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Protocol Information

1V209 (orb1299043)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 1,170.00
5 mg
¥ 1,170.00
10 mg
¥ 1,560.00
25 mg
¥ 2,860.00
50 mg
¥ 3,770.00
100 mg
¥ 5,200.00
200 mg
¥ 7,150.00
DispatchUsually dispatched within 3-5 working days
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