2',4'-DIHYDROXYCHALCONE

SKU: orb1219253

Description

2',4'-Dihydroxychalcone as a compound with Hsp90 inhibitory and antifungal effectsIn the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.

Images & Validation

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Key Properties

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CAS Number	1776-30-3
MW	240.25
Purity	>98% (HPLC)
Formula	C₁₅H₁₂O₃?
SMILES	O=C(C1=CC=C(O)C=C1O)C=CC2=CC=CC=C2
Target	HSP

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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2',4'-DHC

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HSP

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