2',4'-DIHYDROXYCHALCONE

SKU: orb1298601

Description

2',4'-Dihydroxychalcone (2',4'-DHC) is a small molecule inhibitor of Hsp90 with demonstrated antifungal properties. It is used in biochemical research to study heat shock protein function and fungal pathogenesis in both in vitro and cellular assay systems.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1776-30-3
MW	240.25
Purity	98.95% (May vary between batches)
Formula	C₁₅H₁₂O₃
SMILES	Oc1ccc(C(=O)C=Cc2ccccc2)c(O)c1
Target	Antibacterial,HSP
Solubility	DMSO:11 mg/mL (45.79 mM)

Bioactivity

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In Vitro

In the presence of 2',4'-DHC (8 g/mL), radial growth of Aspergillus fumigatus was inhibited 20% compared to the control, and green pigmentation was completely blocked. The expression of the conidiation-associated genes abaA, brlA, and wetA was significantly decreased (approximately 3- to 5-fold) by treatment with 2',4'-DHC. The expression of calcineurin signaling components, cnaA and crzA, was also significantly reduced. The inhibitory effects of 2',4'-DHC on metabolic activity and mycelial growth were significantly enhanced by combination treatment with itraconazole and caspofungin. Docking studies indicated that 2',4'-DHC bind to the ATPase domain of Hsp90. 2',4'-DHC act as an Hsp90-calcinurin pathway inhibitor.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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2',4' DIHYDROXYCHALCONE, 2',4'-DHC, 2',4'DIHYDROXYCHALCONE, 2',4'-DIHYDROXYCHALCONE, HSP90

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Compound Identifiers

PubChem CID

344530 ↗

Key Properties

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No computed properties available.

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